News and Events
Center for Cancer Systems Biology
March 2025
Check out our newest publication:
Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms
Molecular Cell, https://www.sciencedirect.com/science/article/pii/S1097276525001972?dgcid=coauthor
March 2024
NEW on bioRxiv
Harley O'Connor Mount, Malene L Urbanus, Dayag Sheykhkarimli, Atina G Cote, Florent Laval, Georges Coppin, Nishka Kishore, Roujia Li, Kerstin Spirohn-Fitzgerald, Morgan O Petersen, Jennifer J Knapp, Dae-Kyum Kim, Jean-Claude Twizere, Michael A Calderwood, Marc Vidal, Frederick P Roth, Alexander W Ensminger. A comprehensive two-hybrid analysis to explore the L. pneumophila effector-effector interactome.
doi: https://doi.org/10.1101/2024.03.29.587239
Luke Lambourne, Kaia Mattioli, Clarissa Santoso, Gloria Sheynkman, Sachi Inukai, Babita Kaundal, Anna Berenson, Kerstin Spirohn-Fitzgerald, Anukana Bhattacharjee, Elisabeth Rothman, Shaleen Shrestha, Florent Laval, Zhipeng Yang, Deepa Bisht, Jared A. Sewell, Guangyuan Li, Anisa Prasad, Sabrina Phanor, Ryan Lane, Devlin M. Campbell, Toby Hunt, Dawit Balcha, Marinella Gebbia, Jean-Claude Twizere, Tong Hao, Adam, Frankish, Josh A. Riback, Nathan Salomonis, Michael A. Calderwood, David E. Hill, Nidhi Sahni, Marc Vidal, Martha L. Bulyk, Juan I. Fuxman Bass. Widespread variation in molecular interactions and regulatory properties amongtranscription factor isoforms.
doi: https://doi.org/10.1101/2024.03.12.584681
Jessica Lacoste, Marzieh Haghighi, Shahan Haider, Zhen-Yuan Lin, Dmitri Segal, Chloe Reno, Wesley Wei Qian, Xueting Xiong, Hamdah Shafqat-Abbasi, Pearl V Ryder, Rebecca Senft, Beth A Cimini, Frederick P Roth, Michael Calderwood, David Hill, Marc Vidal, S Stephen Yi, Nidhi Sahni, Jian Peng, Anne-Claude Gingras, Shantanu Singh, Anne E Carpenter, Mikko Taipale. Pervasive mislocalization of pathogenic coding variants underlying human disorders.
doi: https://doi.org/10.1101/2023.09.05.556368
Check out our newest publication:
AI-guided pipeline for protein–protein interaction drug discovery identifies a SARS-CoV-2 inhibitor
Molecular System Biology, https://www.embopress.org/doi/full/10.1038/s44320-024-00019-8
February 2023
Congratulations to Maxime Tixhon, who recently received a fellowship of the Belgian American Educational Foundation (BAEF).
October 2022
Check out our newest publication:
A proteome-scale map of the SARS-CoV-2–human contactome
Nature Biotechnology, https://doi.org/10.1038/s41587-022-01475-z
September 2022
Florent Laval received the Josée & Jean Schmets prize 2022-2023, which is issued by the Léon Frédéricq Foundation (Belgium) to support researchers whose work focuses on digestive oncology.
He has also been awarded a complementary funding associated with his Télévie grant for cancer research.
March 2022
Florent Laval received the Herman-van Beneden prize 2021-2022 from the University of Liège, which is awarded to
young researchers for their doctoral research work. Congratulations!
November 2021
2021 Genomics of ASD: Pathways to Genetic Therapies awardees announced. click here
The Simons Foundation Autism Research Initiative (SFARI) is pleased to announce that it intends to fund 17 grants in response to the 2021 Genomics of ASD: Pathways to Genetic Therapies request for applications (RFA).
September 2021
VarChAMP team receive over $8M to study the effects of genetic variation on health.
We are excited to announce our participation in a newly launched multimillion dollar initiative run by NHGRI., the Impact of Genomic Variation on Function (IGVF) Consortium, which aims to bring together scientists and clinicians from all over the world to advance our understanding of genome function and how it contributes to health and disease. Our team comprising the labs of Anne Carpenter (Broad Institute), Fritz Roth (Donnelly Centre for Cellular and Biomolecular Research), Mikko Taipale (Donnelly Centre for Cellular and Biomolecular Research) and Marc Vidal (Dana-Farber) will develop a catalog of experimental data to assist in the classification of missense variants as either pathogenic and capable of causing disease, or benign and harmless.
Read more about the consortium here
https://www.genome.gov/Funded-Programs-Projects/Impact-of-Genomic-Variation-on-Function-Consortium
June 2021
Congratulations to our PhD students Georges Coppin and Florent Laval who both receive a World Excellence Fellowship from WBI.
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Congratulations Julien Olivet on your PhD graduation. We wish you all the best for your next adventure, Dr. Olivet!
CSBC Investigator Highlight - Dr. Juan Fuxman Bass uses systems biology to understand cancer-specific molecular interactions.
Juan Fuxman Bass, a CSBC investigator at Boston University, studied biology as an undergraduate and graduate student at the University of Buenos Aires in Argentina. Now, he uses systems approaches to investigate the role of gene regulatory networks in cancer. In this interview he discusses his career journey, challenges in cancer systems biology, and his CSBC research focused on breast cancer.
Click here to read the full interview.
March 2021
CSHL Network Biology Meeting (https://meetings.cshl.edu/meetings.aspx?meet=network&year=21)
Talk - A reference map of the human binary interactome
Michael A. Calderwood
Talk - Moving towards precision medicine using a network approach
Anupama Yadav
Poster - A new “atlas of binary biophysical interactions” reveals properties of inner- versus outer-complexome organization in yeast
Luke Lambourne
Poster - Mapping the “contactome” of the yeast complexome
Florent Laval
Poster - Edgetic perturbants of the yeast Rpd3 histone deacetylase (HDAC) complex
Julien Olivet
February 2021
Award of an NIAID R21 “Exploring alternate targets for inhibition of virus infection by PPI disruption” to Sylvie van der Werf (Institut Pasteur), Caroline Demeret (Institut Pastuer) and Mike Calderwood (Dana-Farber) which aims to develop a pipeline to identify compounds that inhibit key viral-host interactions, hence preventing viral infection and avoiding viral resistance.
November 2020
We say goodbye to Soon Gang Choi and wish him all the best for his new position at Ginkgo!
September 2020
Award of an NHGRI R21 “Development of an OPTogenetic InteractoMics Assay (OPTIMA)” to Yves Jacob (institute Pasteur) and Mike Calderwood (Dana-Farber) which aims to combine the most advanced development in bioluminescence, optogenetics, DNA-barcoding and next generation sequencing to develop new tools to map protein-protein interactions.
July 2020
We say goodbye to Yang Wang and wish him all the best for his new position at Ginkgo!
We say goodbye to Aaron Richardson and wish him all the best for his new position at Vertex!
Job Dekker elected to European Molecular Biology Organization
Read full article
We say goodbye to Gloria Sheynkman and wish her all the best for her new Assistant Professor position at University of Virginia School of Medicine!!
June 2020
May 2020
Check out our newest publication:
ORF Capture-Seq as a versatile method for targeted identification of full-length isoforms.
Nat Commun. 2020 May 11;11(1):2326.
April 2020
World’s Largest Map of Protein Connections Holds Clues to Health and Disease
Read article
We're excited to announce that our paper is now available at Nature!!
Luck et al, Nature 2020
http://www.interactome-atlas.org/
March 2020
Yadav et al, Curr Opin Biotechnol. 2020 Mar
Precision medicine - networks to the rescue.
November 2019
We say goodbye to Katja Luck and wish her all the best for her new position at IMB Mainz (Germany)!
2019 Anne and Max Tanenbaum Symposium: Exploring extraterrestrial life, alpine ice patch archeology and systems biology
September 2019
Congratulations to the winners
Soon Gang Choi and Julien Olivet
who both won awards at the
15th Dana-Farber Postdoc & Graduate Student Retreat!
Soon Gang received the Travel Award and Julien received the Best Oral Presentation Award.
Group Picture from the 2019 CCSB/PSB Retreat in Gloucester.
August 2019
Our newest publication "Maximizing binary interactome mapping with a minimal number of assays" is now available on PubMed!!
PMID: 31467278
Monday, September 16th - Wednesday, September 18th. Please join us for this year's CCSB/PSB retreat, hosted jointly by Dana-Farber's Center for Cancer Systems Biology (CCSB) and UMASS Program in Systems Biology (PSB) at Beauport Hotel in Gloucester, MA.
Congratulations to Georges Coppin who received an achievement certificate for an outstanding poster at the Cancer Biology Retreat at UMass Boston!
March/April 2019
Excited to announce that our recent manuscripts are available at bioRxiv!
“A reference map of the human protein interactome”
https://www.biorxiv.org/content/10.1101/605451v1
“ORF Capture-Seq: a versatile method for targeted identification of full-length isoforms”
https://www.biorxiv.org/content/10.1101/604157v1
"Maximizing binary interactome mapping with a minimal number of assays"
https://www.biorxiv.org/content/10.1101/530790v2
March 2019
Congratulations to István A. Kovács and the team on the Nature Communications publication of
“Network-based prediction of protein interactions”
PMID: 30886144
January 2019
December 2018
Congratulations to Georges Coppin who was awarded a "Fonds de la Recherche Scientifique - FNRS" fellowship!
November 2018
October 2018
Congratulations to Julien Olivet who was awarded a fellowship and a grant! He is the recipient of the Wallonia-Brussels International (WBI)-World Excellence Fellowship in Life Sciences and the Belgian F.R.S.-FNRS-Televie Grant for Cancer Research.
Congratulations to Gloria Sheynkman who was awarded a fellowship and a grant! She is the recipient of the Charles A. King Trust Postdoctoral Research Fellowship and the Melanoma Research Foundation Career Development Award.Gloria Sheynkman
September 2018
Group Picture from the 2018 CCSB/PSB Retreat in Gloucester.
Dr. Marc Vidal and Dr. David Hill will be attending and presenting at the 2018 CSBC Annual Investigators Meeting at NIH.
This year's CCSB/PSB retreat was held on Monday, September 17th - Wednesday, September 19th. The annual retreat, hosted jointly by Dana-Farber's Center for Cancer Systems Biology (CCSB) and UMASS Program in Systems Biology (PSB), was a huge success. Thank you to everyone who participated. Stay tuned for the 2019 dates.
September 2017
Monday, September 11th - Wednesday, September 13th. Please join us for this year's CCSB/PSB retreat, hosted jointly by Dana-Farber's Center for Cancer Systems Biology (CCSB) and UMASS Program in Systems Biology (PSB).
At Beauport Hotel in Gloucester, MA.
June 2017
Michael Calderwood, Tijana Milenkovic and Amitabh Sharma are running a meeting on Network Medicine at the International School and Conference on Network Science 2017 in Indianapolis.
David E. Hill is speaking at the International Symposium on Immunology 2017 in Tokyo.
May 2017
Our review on human proteome-scale interactomics is published and decorated the TiBS cover.
Julien Olivet is presenting his work at the Cancer Biology Seminar Series.
Luke Lambourne joined the CCSB !
March 2017
(Video) CSHL Keynote: Dr. Marc Vidal, Dana-Farber Cancer Institute/Harvard Medical School
February 2017
Genetics Retreat 2017
Monday, February 27 and Tuesday, February 28
8:00 AM - 5:00 PM
Broad Institute
7 Cambridge Center, Cambridge, MA 02142
December 2016
Anupama Yadav joined the CCSB !
Learn more about her work
September 2016
